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Saline Infusion Sonohysterography

Saline Infusion Sonohysterography, SIS is used to evaluate the uterus and the uterine (endometrial) cavity.

It is a procedure in which a physician injects sterile saline into the uterine cavity with ultrasound guidance. It allows your doctor to identify any abnormalities of the uterus, including congenital anomalies, scarring, endometrial polyps and fibroids that might affect chances of conception or pregnancy.

What is the process?

SISs are performed between days five and 10 of the menstrual cycle. A speculum is inserted into the vagina and the cervix is cleaned with a Betadine solution. A small catheter is passed through the cervix, and sterile saline is gently injected while vaginal ultrasound is performed. The entire procedure takes about 15 minutes. No anesthesia is required, and any pain after the procedure is minimal.

SIS involves the following steps:

  1. Call the office the first business day after your period begins to schedule the procedure. Please notify our office staff if there is any doubt about the normalcy of your period so a pregnancy test can be performed. We must be certain you are not pregnant before doing an SIS.
  2. Because you may experience mild cramping with this procedure, you may want to take either 600 mg of Ibuprofen (Advil, Motrin) or 1000 mg of Acetaminophen (Tylenol) 45 minutes before the procedure.
  3. Take the prescribed antibiotic twice on the day of the procedure.


An SIS is routinely done prior to in vitro fertilization, before the embryo transfer. Your physician may also perform this test if you have abnormal bleeding, a history of uterine surgery or a history of recurrent miscarriages. Your physician will be able to review the results with you immediately after the procedure. The next steps will depend on the findings.

Are there risks?

You may experience some mild cramping, discharge or spotting during or after the procedure. These symptoms usually disappear very quickly after the procedure. Less than 1 percent of all patients undergoing SIS may develop an infection as a result of the procedure. Should you develop a fever or unusual pain after the procedure, please notify your physician.